Blood-brain barrier disruption and intra-arterial methotrexate-based therapy for newly diagnosed primary CNS lymphoma: a multi-institutional experience. Categories: Blood Brain Barrier Author: Angelov L, Barnett GH, Bell S, Doolittle ND, Ference S, Haluska M, Hedrick NA, Jahnke K, Kraemer DF, Lacy CA, McGregor J, Neuwelt EA., Peereboom DM, Shalom E, Siegal T, Sorenson L, Stevens G, Tyson RM